Vincent (Vince) Quy Tran

    Profile

    Hi,

    1 // I am a scientist that works at the intersection of AI and experimental biology to engineer better biologics for research and human therapeutics. I am especially interested in the development of machine learning methods for accelerated protein engineering. I am currently a postdoctoral researcher at the Arc Institute, working with Dr. Patrick D. Hsu.

    2 // Previously, I was an undergraduate at UCLA, where I studied HIV drug resistance mechanisms and received my B.Sc. in Biochemistry. I received my PhD in Chemistry from UCB, working in the Hsu Lab. During my PhD, I investigated methods to engineer genome/transcriptome-editing proteins including CRISPR-Cas systems and large serine recombinases.

    3 // Apart from my work in biology, you may find me fixing my serve at the tennis court, replaying songs by Porter Robinson, or holding a ZV-E1 and filming random vlogs.

    Selected Publications

    Rapid directed evolution guided by protein language models and epistatic interactionsV. Q. Tran, M. Nemeth, L. J. Bartie, S. S. Chandrasekaran, A. Fanton, H. C. Moon, B. L. Hie, S. Konermann, P. D. Hsu.Science. 2026
    Simulating 500 million years of evolution with a language modelT. Hayes*, R. Rao*, H. Akin*, N. J. Sofroniew*, D. Oktay*, Z. Lin*, R. Verkuil*, V. Q. Tran, J. Deaton, M. Wiggert, R. Badkundri, I. Shafkat, J. Gong, A. Derry, R. S. Molina, N. Thomas, Y. A. Khan, C. Mishra, C. Kim, L. J. Bartie, M. Nemeth, P. D. Hsu, T. Sercu, S. Candido, A. Rives.Science. 2025
    Site-Specific DNA Insertion into the Human Genome with Engineered RecombinasesA. Fanton, L. J. Bartie, J. Q. Martins, V. Q. Tran, L. Goudy, M. G. Durrant, J. Wei, A. Pawluk, S. Konermann, A. Marson, L. A. Gilbert, P. D. Hsu.Nature Biotechnology. 2025