Vincent (Vince) Quy Tran

Profile

Hi,

1 // I am a scientist that works at the intersection of AI and experimental biology to engineer better biologics for research and human therapeutics. I am especially interested in the development of machine learning methods for accelerated protein engineering. I am currently a founding scientist at Onava, developing Onava’s platform, which tightly integrates agentic AI with protein engineering to develop therapeutics.

2 // Previously, I was an undergraduate at UCLA, where I studied HIV drug resistance mechanisms and received my B.Sc. in Biochemistry. I received my PhD in Chemistry from UCB, working in the Hsu Lab. During my PhD, I investigated methods to engineer genome/transcriptome-editing proteins including CRISPR-Cas systems and large serine recombinases. I then continued as a postdoctoral researcher at the Arc Institute, working with Dr. Patrick D. Hsu.

3 // Apart from my work in biology, you may find me fixing my serve at the tennis court, replaying songs by Porter Robinson, or holding a ZV-E1 and filming random vlogs.

// path so far
  1. UCLAB.Sc. BiochemistrySep 2014 – Jun 2018
  2. YalePhD studiesAug 2018 – Dec 2019
  3. UC BerkeleyPhD ChemistryJan 2020 – Dec 2024
  4. Arc InstitutePostdocJan 2025 – May 2026
  5. OnavaFounding ScientistJul 2026 – present

Selected Publications

Rapid directed evolution guided by protein language models and epistatic interactionsV. Q. Tran, M. Nemeth, L. J. Bartie, S. S. Chandrasekaran, A. Fanton, H. C. Moon, B. L. Hie, S. Konermann, P. D. Hsu.Science. 2026
Simulating 500 million years of evolution with a language modelT. Hayes*, R. Rao*, H. Akin*, N. J. Sofroniew*, D. Oktay*, Z. Lin*, R. Verkuil*, V. Q. Tran, J. Deaton, M. Wiggert, R. Badkundri, I. Shafkat, J. Gong, A. Derry, R. S. Molina, N. Thomas, Y. A. Khan, C. Mishra, C. Kim, L. J. Bartie, M. Nemeth, P. D. Hsu, T. Sercu, S. Candido, A. Rives.Science. 2025
Site-Specific DNA Insertion into the Human Genome with Engineered RecombinasesA. Fanton, L. J. Bartie, J. Q. Martins, V. Q. Tran, L. Goudy, M. G. Durrant, J. Wei, A. Pawluk, S. Konermann, A. Marson, L. A. Gilbert, P. D. Hsu.Nature Biotechnology. 2025